个人简介      

焦丽，博士，副研究员，1987年06月出生。本科、硕士研究生和博士研究生均就读于吉林大学。博士研究生阶段于德国海德堡大学进行联合培养,从事疾病致病机理研究。2016年06月毕业于吉林大学白求恩医学院，获医学博士学位。入职中国医学科学院医学生物学研究所以来，进行病毒致病机制研究工作。研究领域为重大疾病的感染免疫以及代谢机理研究，主要致力于人类重大疾病的感染和免疫、炎症、信号传导和代谢调控等方面，包括病毒的致病机制、衰老机制和代谢相关疾病研究。主要贡献发表在Gastroenterology，Signal Transduct Target Ther和Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism等杂志上，总计发表SCI论文10篇，影响因子总和146.9，其中第一作者（包含共同）论文5篇，影响因子总和87.3，单篇高于30分2篇，Q1区4篇。以第一作者发表发表国际会议摘要3篇。2017.07归国工作后主持国家自然科学基金-青年基金、北京协和青年奖掖项目以及协和青年教师项目各一项，共参与医学科学院医学与重大科技创新工程重大协同项目两项，参与德国国家科学基金DFG项目两项，累计获得科研经费两百余万元。获得2019年云南省“云岭青年人才”称号。

所属专业：

生物化学与分子生物学

研究方向：

重大疾病的感染免疫和代谢调控机制

联系方式 ：

TEL: 18288771497

发表论文：

（1）Ying Xie, Li Jiao#, Qiangming Sun#; Dengue Virus and Lipid Metabolism: Unraveling the Interplay for Future Therapeutic Approaches, Emerging Microbes & Infections, 2025 Mar 10:2477647. Online ahead of print（#共通讯作者; IF:8.4；Q1 区）.

（2）Li Jiao, Wenxin Shao, Wenqi Quan, Longjiang Xu, Penghui Liu, Jinling Yang, Xiaozhong Peng. iPLA2β loss leads to age-related cognitive decline and neuroinflammation by disrupting neuronal mitophagy. J Neuroinflammation. 2024 Sep 18;21(1):228. （IF:9.3；Q1区）.

（3）Li Jiao*; Yun Yang*; Wenhai Yu*; Yuan Zhao*; Haiting Long; Jiahong Gao; Kaiyun Ding; Chunxia Ma; Jingmei Li; Siwen Zhao; Haixuan Wang; Haiyan Li; Mengli Yang; Jingwen Xu; Junbin Wang; Jing Yang; Dexuan Kuang; Fangyu Luo; Xingli Qian; Longjiang Xu; Bin Yin; Wei Liu; Hongqi Liu#; Shuaiyao Lu#; Xiaozhong Peng#; The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 6(1): 169-170 （IF:38.1；Q1区）.

（4）Li Jiao*; Haiyan Li*; Jingwen Xu*; Mengli Yang*; Chunxia Ma; Jingmei Li; Siwen Zhao; Haixuan Wang; Yun Yang; Wenhai Yu; Junbin Wang; Jing Yang; Haiting Long; Jiahong Gao; Kaiyun Ding; Daoju Wu; Dexuan Kuang; Yuan Zhao; Jiansheng Liu; Shuaiyao Lu#; Hongqi Liu#; Xiaozhong Peng#; The Gastrointestinal Tract Is an Alternative Route for SARS-CoV-2 Infection in a Nonhuman Primate Model, Gastroenterology, 2021, S0016-5085(20): 35527-X （IF:33.8；Q1区）.

（5）Li Jiao; Hongying Gan-Schreier; Xingya Zhu; Wang Wei; Sabine Tuma-Kellner; Gerhard Liebisch; Wolfgang Stremmel; Walee Chamulitrat# ; Ageing sensitized by iPLA2β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017, S1388(1981): 30187 （IF:6.2；Q1区）.

（6）Li Jiao; Hongying Gan-Schreier; Sabine Tuma-Kellner; Wolfgang Stremmel; Walee Chamulitrat#; Sensitization to autoimmune hepatitis in group VIA calcium-independent phospholipase A2-null mice led to duodenal villous atrophy with apoptosis, goblet cell hyperplasia and leaked bile acids, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2015, 1852(8): 1646-1657 （IF:5.5；Q1区）.

（7）Li Jiao; Johannes Inhoffen; Hongying Gan-Schreier; Sabine Tuma-Kellner; Wolfgang Stremmel; Zhiwei Sun; Walee Chamulitrat#; Deficiency of Group VIA Phospholipase A2 (iPLA2β) Renders Susceptibility for Chemical-Induced Colitis, Dig Dis Sci , 2015.12, 60(12): 3590-3602（IF:3.5）.