姓 名

李鸿钧

职 务

李鸿钧课题组组长

职 称

研究员

一级学科

生物学

二级学科

生物化学与分子生物学

联系邮箱

lihj6912@163.com

个人简介

一、教育经历

（1）1998-09 至 2003-07, 北京协和医学院, 生物化学与分子生物学, 博士 

（2）1987-09 至 1993-07, 华西医科大学, 预防医学，学士

二、工作经历

（1）2011-09 至 今, 中国医学科学院, 医学生物学研究所, 研究员，科室主任，PI

（2）2006.09-2011.08, 中国医学科学院, 医学生物学研究所, 副研究员，科室副主任

（3）2003.07-2006.08，中国医学科学院, 医学生物学研究所, 助理研究员

（4）1993.07-2003.06  中国医学科学院, 医学生物学研究所, 研究实习员

三、主要进修学习经历

2017.12.11-2017.12.15，中国疾病预防控制中心国家免疫规划循证决策培训班暨高级研讨会

2009,8—2009.10， 美国CDC呼吸道肠道病毒实验室轮状病毒灭活疫苗研发相关培训

代表性成果

一、论文

(1) Wang J, Hu X, Wu J, Lin X, Chen R, Lu C, Song X, Leng Q, Li Y, Kuang X, Li J, Yao L, Tang X, Ye J, Zhang G, Sun M, Zhou Y, Li H. ML241 Antagonizes ERK 1/2 Activation and Inhibits Rotavirus Proliferation. Viruses, 2024,16(4):623.

(2) Lu C, Li Y, Chen R, Hu X, Leng Q, Song X, Lin X, Ye J, Wang J, Li J, Yao L, Tang X, Kuang X, Zhang G, Sun M, Zhou Y, Li H. Safety, Immunogenicity, and Mechanism of a Rotavirus mRNA-LNP Vaccine in Mice. Viruses, 2024 ,16(2):211.

(3) Jin-Yuan Wu, Wei Zhang, Jing Pu, Yan Liu, Li-Li Huang, Yan Zhou, Jia-Mei Gao, Jie-Bing Tan, Xin-Ling Liu , Jing Yang , Xiao-Chen Lin, Guang-Wei Feng, Na Yin, Rong Chen a, Xiao-Qing Hu , Shan Yi, Jun Ye , Xiang-Jing Kuang , Yan Wang , Guang-Ming Zhang, Mao-Sheng Sun, Yan-Xia Wang , Zhong-Yu Hu, Jing-Si Yang , Hong-Jun Li. A randomized, double-blind, placebo-controlled phase I clinical trial of rotavirus inactivated vaccine (Vero cell) in a healthy adult population aged 18–49 years to assess safety and preliminary observation of immunogenicity. Vaccine2024, doi.org/10.1016/j.vaccine.2024.05.014

(4) Yan Zhou; Jinyuan Wu; Xiaoqing Hu; Rong Chen; Xiaochen Lin; Na Yin; Chenxing Lu; Jun Ye; Yongmei Zhao; Xiaopeng Song; Zexin Song; Jinlan Wang; Yan Li; Jinmei Li; Guangming Zhang; Maosheng Sun; Hongjun Li ; Immunogenicity of inactivated rotavirus in rhesus monkey, and assessment of immunologic mechanisms, Human Vaccines & Immunotherapeutics, 2023, 19(1): 2189598

(5) Yan Zhou; Xiaoqing Hu; Rong Chen; Jinyuan Wu; Xiaochen Lin; Chenxing Lu; Na Yin; Yaya Tang; Peng Shi; Zexin Song; Yongmei Zhao; Maosheng Sun; Hongjun Li ; Impact of maternal and pre-existing antibodies on immunogenicity of inactivated rotavirus vaccines, Vaccine, 2022, 40(28): 3843-3850

(6) Na Yin, Jinyuan Wu, Xiangjing Kuang, Xiaochen Lin, Yan Zhou, Shan Yi, Xiaoqing Hu, Rong Chen, Yaling Liu, Jun Ye, Zhanlong He, Maosheng Sun & Hongjun Li. Vaccination of pregnant rhesus monkeys with inactivated rotavirus as a model for achieving protection from rotavirus SA11 infection in the offspring. Human Vaccines & Immunotherapeutics.2022, 17 (12): 5656–5665

(7) Yaya Tang, Yan Zhou and Hong-Jun Li. Advances in mesenchymal stem cell exosomes: a review. Stem Cell Research Therapy，2021，12(1):71-82

(8) Zhou, Y; Chen, L; Du, J; Hu, X; Xie, Y; Wu, J; Lin, X; Yin, N; Sun, M; Li, H.; MicroRNA7 Inhibits Rotavirus Replication by Targeting Viral NSP5 In Vivo and In Vitro, Viruses, 2020, 12(2): 209

(9) Zhou, Y; Qiao, H; Yin, N; Chen, L; Xie, Y; Wu, J; Du, J; Lin, X; Wang, Y; Liu, Y; Yi, S; Zhang, G; Sun, M; He, Z; Li, H. ; Immune and cytokine/chemokine responses of PBMCs in rotavirus infected rhesus infants and their significance in viral pathogenesis, Journal of Medical Virology, 2019, 91(8): 1448-1469

二、专利

(1)李鸿钧; 刘洋；林晓晨；周艳; 吴晋元；解裕萍。 一种基于原核表达诺如病毒抗原表位的亚单位疫苗及其制备方法, 2022-06- 03, 中国, ZL201811628948.6 (发明专利)

(2) 李鸿钧; 孙茂盛；吴晋元；周艳; 张光明; 易山; 尹娜 ; 解裕萍。人轮状病毒毒种ZTR-18毒株及其分离，培养与鉴定, 202-05-04, 中国, ZL201510984614.2 (发明专利)

(3) Zhou Yan; Li Hongjun; Wu Jinyuan; Xie Yuping; Yin Na; Yi Shan; Zhang Guangming; Sun Maosheng ; miR-125a-3p targeting PTB protein and use thereof in preparing anti-rotavirus drugs, 2017-10-27, 其他国家, 2017417169 (专利)

荣誉奖励

      李鸿钧(1/7); Ad-NTN-TH联合干细胞治疗帕金森氏病模型猴的研究, 云南省人民政府, 科技进步, 其他, 2017(李鸿钧; 周艳; 孙茂盛; 吴晋元; 和占龙; 尹娜; 鲁帅尧) (科研奖励)

社会兼职

     国家免疫规划技术工作组成员；云南省微生物与免疫学会、云南省微生态学会委员；《中华微生物和免疫学杂志》、《生物学杂志》、《病毒学杂志》编委