个人简介

    杜廷福，男，汉族，毕业于北京协和医学院基础医学研究所，生物化学与分子生物学专业，获理学博士学位。云南省“兴滇”青年人才（2024）、云南省医学后备人才（2018），发表论文30余篇，其中以第一作者和并列第一作者发表SCI论文10余篇，主持国家自然科学基金1项、省部级课题5项。在工作期间，参与完成多项疫苗和药物的有效性评价和安全性评价工作，同时开展相关疾病的致病机制研究等工作。

所属专业：生物化学与分子生物学

研究方向：表观遗传修饰在病原与宿主中的作用及其调控机制研究

联系方式 ：dutingfu@imbcams.com.cn

发表论文：

1. Tingfu Du^#, Ruixue Liu^#, Xintian Zhang^#, Longying Shen^#, Cong Tang, Junbin Wang, Yu Cheng, Wenhai Yu, Bin Yin, Shuaiyao Lu*, Xiandao Pan*, Xiaozhong Peng*. Lycorine derivative inhibit SARS-CoV-2 replication by reducing −1 programmed ribosomal frameshifting via targeting ZAP. MedComm, 2026. 7(4): p. e70715.

2. Tanxiu Chen^#, Ruimin Zhu^#, Tingfu Du^#, Hao Yang, Xintian Zhang, Zhixing Wang, Yong Zhang, Wenqi Quan, Bin Yin, Yunpeng Liu*, Shuaiyao Lu*, Xiaozhong Peng*. Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting. Signal Transduct Target Ther, 2025. 10(1): p. 192.

3. Tingfu Du^#, Guoxiang Li^#, Qinglan Zong, Haiyu Luo, Yue Pan, Kaili Ma*. Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration. Immun Ageing, 2024. 21(1): p. 47.

4. Tingfu Du^#,Chunchun Gao^#, Shuaiyao Lu^#, Qianlan Liu^#, Yun Yang^#, Wenhai Yu, Wenjie Li, Yong Qiao Sun, Cong Tang, Junbin Wang, Jiahong Gao, Yong Zhang, Fangyu Luo, Ying Yang*, Yun-Gui Yang*, Xiaozhong Peng*. Differential transcriptomic landscapes of SARS-CoV-2 Variants in Multi-organs from Infected Rhesus macaques. Genomics Proteomics & Bioinformatics, 2023. Jul 12.

5. Jiandong Shi^#, Tingfu Du^#, Junbin Wang^#, Cong Tang^#, Mengyue Lei, Wenhai Yu, Yun Yang, Ying Ma, Pu Huang, Hongli Chen, Xu Wang, Jing Sun, Haixuan Wang, Yong Zhang, Fangyu Luo, Qing Huang, Bai Li, Shuaiyao Lu*, Yunzhang Hu*, Xiaozhong Peng*. Aryl hydrocarbon receptor is a proviral host factor and a candidate pan-SARS-CoV-2 therapeutic target. Science advances, 2023. 9 (22).

6. Yun Yang^#, Tingfu Du^#, Wenhai Yu^#, Yanan Zhou^#, Chengyun Yang^#, Dexuan Kuang, Junbin Wang, Cong Tang, Haixuan Wang, Yuan Zhao, Hao Yang, Qing Huang, Daoju Wu, Bai Li, Qiangming Sun*, Hongqi Liu*, Shuaiyao Lu*, Xiaozhong Peng*. Single-cell transcriptomic atlas of distinct early immune responses induced by  SARS-CoV-2 Proto or its variants in rhesus monkey. MedComm, 2023. 4(6): p. e432.

7. Tingfu Du^#, Guoxiang Li^#, Haiyu Luo, Yue Pan, Qi Xu*, Kaili Ma*. Hippocampal alpha-synuclein mediates depressive-like behaviors. Brain, Behavior, and Immunity; 2021 Mar 26.

8. Dandan Wan^#, Tingfu Du^#, Weiqi Hong^#, Li Chen, Haiying Que, Shuaiyao Lu*, Xiaozhong Peng*, Neurological complications and infection mechanism of SARS-CoV-2. Signal Transduction and Targeted Therapy, 2021. 6(1): p. 406. (Review)

9. Tingfu Du^#, Guoxiang Li^#, Jinling Yang, Kaili Ma*. RNA demethylase Alkbh5 is widely expressed in neurons and decreased during brain development. Brain Research Bulletin, 2020. 163: p. 150-159.

10. Tingfu Du^#,Zhengcun Wu^#, Haiyu Luo, Shuaiyao Lu and Kaili Ma^*. Injection of α-syn98 aggregates into the Brain Triggers α-synuclein Pathology and an Inflammatory Response. Front. Mol. Neurosci, 2019; 12.